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CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids. Nature Communications.  2022

Lo M, Sharir A, Paul MD, Torosyan H, AgnewC, Li A, Neben C, MarangoniP, XuL, RaleighDR, Jura N, Klein OD.


Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar toothdevelopment. Development. 2021

Kim R, Yu T, Li J, Prochazka J, Sharir A, Green J and Klein OD


From bite to byte: Dental structures resolved at a single-cell resolution. Journal of Dental Research. Invited Review. 2021

Fresia R, Marangoni P, Burstyn-Cohen T and Sharir A**Corresponding author


KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020

Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Alzamora MDP, Kogan SC, Sharir A, Keefe SH,Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D,Klein O,Tuveson D, Braun BS, Shannon K.


A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nature Cell Biology. 2019

Sharir A, Marangoni P, ZilionisR, Wan M, Wald T, Hu J, Kawaguchi K, Epstein L, Harrington K, Pagella P, MitsiadisT, Siebel CW, Klein AM


Mechanoresponsive stem cells acquireneural crest fate in jaw regeneration. Nature. 2018

Chase RR, Carter AC, Salhotra A, Marecic O, Lopez ML, Sharir A, Wan DC, Klein OD, Chang HY, and Longaker MT

Sharir lab for dental and craniofacial regeneration Phone: +972-2-675-7329  e-mail

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Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10, and Wnt5a. Hum Mol Genet. 2017

Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD


Human iPS cell-derived neurons uncover the impact of increased Ras signaling in Costello Syndrome. J Neurosci. 2016

Rooney GE, Goodwin AF, Depeille P, Sharir A, Schofield CM, Yeh E, Roose JP, Klein OD, Rauen KA, Weiss LA, Ullian EM.


Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol. 2016

Sharir A and Klein OD.


Loss of osteoblast Runx3 produces severe congenital osteopenia. Mol Cell Biol. 2015

Bauer O, Sharir A, Kimura A, Hantisteanu S, Takeda S, Groner Y.


Continuously Growing Rodent Molars Result from a Predictable Quantitative Evolutionary Change over 50 Million Years. Cell Rep. 2015

Mushegyan V, EronenJT, Lawing AM, Sharir A, Janis CM, Jernvall J, Klein OD


Isometric Scaling in Developing Long Bones Is Achieved by an optimal epiphyseal growth balance. PLoS Biol. 2015

Stern T, Aviram R, Rot C, Galili T, Sharir A, Kalish, Achrai N, Keller Y, Shahar R, Zelzer E.


Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation. Hum Mol Genet. 2014

Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD.


Tendon-bone attachment unit is formed modularly by a distinct pool of Scx-and Sox9-positive progenitors. Development. 2013

Blitz E, Sharir A, Akiyama H, Zelzer E.


A temporary decrease in mineral density in perinatal mouse long bones. Bone. 2012

Sharir A, Milgram J, Dubnov-Raz G, Zelzer E, Shahar R.


Bone mineralization proceeds through intracellular amorphous calcium phosphate loaded vesicles: A cryo electron microscopy study. Journal of Structural Biology. 2011

Mahamid J, Sharir A, Zelzer E, Addadi L and Weiner S.


Muscle force regulates bone shaping for optimal load-bearing capacity during embryogenesis. Development. 2011

Sharir A, Stern T, Rot C, Shahar R and Zelzer E.


High resolution 3D imaging of exvivo biological samples by micro–CT. Journal of Visual Experiments. 2011

Sharir A, Stern T, Rot C, Shahar Sharir A, Ramniceanu G, and Brumfeld V. and Zelzer E.


The canine baculum: The structure and mechanical properties of an unusual bone. Journal of Structural Biology. 2011

Sharir A, Israeli D, Milgram J, Currey J.D, Monsonego-Ornan E and Shahar R.


TGF-β in Tendon: The Path from Muscle Force to ECM Composition. Current Biology. 2011

Sharir A*and Zelzer E.

2010 and Earlier

Bone vascularization and trabecular bone formation are mediated by PKB alpha/Akt1 in a gene-dosage-dependent manner: in vivo and ex vivo MRI. Magn Reson Med. 2010

Vandoorne K, Magland J, Plaks V, Sharir A, Zelzer E, Wehrli F, Hemmings BA, Harmelin A and Neeman M.


Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded. Dev Dyn. 2010

Lyashenko N, Weissenböck M, Sharir A, Erben RG, Minami Y and Hartmann C

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The influence of severe prolonged exercise restriction on the mechanical and structural properties of bone in an avian model. Vet J. 2010

Shipov A, Sharir A, Zelzer E, Milgram J, Monsonego-Ornan E and Shahar R.


Determining the elastic modulus of mouse cortical bone using electronic speckle pattern interferometry (ESPI) and micro computed tomography: a new approach for characterizing small-bone material properties. Bone. 2009

Chattah NL, Sharir A, Weiner S and Shahar R.


Muscle contraction is necessary to maintain joint progenitor cell fate. Dev Cell. 2009

Kahn J, Shwartz Y, Blitz E, Krief S, Sharir A, Breitel DA, Rattenbach R, Relaix F, Maire P, Rountree RB, Kingsley DM and Zelzer E.


Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of BMP4 at the tendon-skeleton junction. Dev Cell. 2009

Blitz E, Viukov S, Sharir A, Shwartz Y, Galloway JL, Pryce BA, Johnson RL, Tabin CJ, Schweitzer R and Zelzer E.


Optical metrology methods for mechanical testing of whole bones. Vet J. 2009

Barak M.M, Sharir A and Shahar R


The effect of weight loading and subsequent release from loading on the postnatal skeleton. Bone. 2008

Reich A*, Sharir A*, Zelzer E, Hacker L, Monsonego-Ornan E and Shahar R. *equal contribution.


CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules. J Exp Med. 2008

Shivtiel S, Kollet O, Lapid K, Schajnovitz A, Goichberg P, Kalinkovich A, Shezen E, Tesio M, Netzer N, Petit I, Sharir A and Lapidot T.


Amorphous calcium phosphate is a major component of the forming fin bones of zebrafish: Indications for an amorphous precursor phase. PNAS. 2008

Mahamid J, Sharir A, Addadi L and Weiner S.


Whole bone mechanics and mechanical testing. Vet J. 2008

Sharir A, Barak M.M and Shahar R


HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis. Development. 2007

Amarilio R, Viukov SV, Sharir A, Eshkar-Oren I, Johnson RS and Zelzer E. (2007).elzer E, Milgram J, Monsonego-Ornan E and Shahar R.


Structural and functional anatomy of theneckmusculature of the dog (Canis familiaris). Journal of Anatomy 2006

Sharir A, Milgram J and Shahar R.

Sharir lab for dental and craniofacial regeneration Phone: +972-2-675-7329  e-mail

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